纳米医学应用中纳米颗粒的免疫调节作用。

Jiao Qing, Li Liwen, Mu Qingxin, Zhang Qiu

School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA ; Department of Materials Science & Engineering, University of Washington, Seattle, WA 98125, USA.

Biomed Res Int. 2014;2014:426028. doi: 10.1155/2014/426028. Epub 2014 May 20.

Nanoparticles (NPs) have promising applications in medicine. Immune system is an important protective system to defend organisms from non-self matters. NPs interact with the immune system and modulate its function, leading to immunosuppression or immunostimulation. These modulating effects may bring benefits or danger. Compositions, sizes, and surface chemistry, and so forth, affect these immunomodulations. Here we give an overview of the relationship between the physicochemical properties of NPs, which are candidates to be applied in medicine, and their immunomodulation properties.

纳米颗粒（NPs）在医学领域有着广阔的应用前景。免疫系统是保护机体抵御外来物质的重要防御系统。纳米颗粒与免疫系统相互作用并调节其功能，从而导致免疫抑制或免疫刺激。这些调节作用可能带来益处或危险。纳米颗粒的组成、大小、表面化学性质等会影响这些免疫调节作用。在此，我们概述了有望应用于医学的纳米颗粒的物理化学性质与其免疫调节特性之间的关系。