Department of Pharmaceutical Technology, Faculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
Department of Pharmaceutical Technology, Faculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic; Faculty of Chemical Technology, University of Chemistry and Technology, Technicka 5, 166 28 Prague, Czech Republic.
Eur J Pharm Sci. 2020 Jan 15;142:105139. doi: 10.1016/j.ejps.2019.105139. Epub 2019 Nov 5.
The potential of nanotechnology has been explored throughout fields of medicine and found its application also in immunology. Given the crucial defence role and disseminated character of the immune system, the idea of using its strength in treatment has always been very attractive. Immunomodulation is an optimisation of the immune response both in terms of immunosuppression in autoimmune disorders and immunostimulation in vaccination or cancer immunotherapy. For these purposes, a wide range of nanomaterials has been investigated to influence the immune system directly by their composition itself or indirectly as intact carriers of the active. This review attempts to refer to nanomaterials and drug delivery systems utilised to modulate the immune response. It lists various structural types of nanoparticles discussing their composition and interplay with the immune system. Throughout the literature, both novel and traditional nanoparticles were utilised. The most progressive ones extend beyond the delivery of a single substance moving towards combined drug delivery systems and stimuli-responsive formulations.
纳米技术的潜力已经在医学领域得到了广泛探索，并在免疫学中找到了应用。鉴于免疫系统的关键防御作用和分布特征，利用其力量进行治疗的想法一直非常有吸引力。免疫调节是对免疫反应的优化，既可以在自身免疫性疾病中进行免疫抑制，也可以在疫苗接种或癌症免疫治疗中进行免疫刺激。为此，已经研究了广泛的纳米材料，通过其自身的组成或作为活性物质的完整载体来直接影响免疫系统。本综述试图参考用于调节免疫反应的纳米材料和药物传递系统。它列出了各种结构类型的纳米颗粒，讨论了它们的组成和与免疫系统的相互作用。在整个文献中，既使用了新型纳米颗粒，也使用了传统纳米颗粒。最先进的纳米颗粒不仅限于单一物质的传递，而是朝着联合药物传递系统和刺激响应制剂的方向发展。
