1Center for Molecular Studies of the Cell, Biomedical Sciences Institute, Faculty of Medicine, Universidad de Chile; and 2Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.
Exerc Sport Sci Rev. 2014 Jul;42(3):110-6. doi: 10.1249/JES.0000000000000017.
Tetanic electrical stimulation releases adenosine triphosphate (ATP) from muscle fibers through pannexin-1 channels in a frequency-dependent manner; extracellular ATP activates signals that ultimately regulate gene expression and is able to increase glucose transport through activation of P2Y receptors, phosphatidylinositol 3-kinase, Akt, and AS160. We hypothesize that this mechanism is an important link between exercise and the regulation of muscle fiber plasticity and metabolism.
强直性电刺激通过嘌呤能受体 P2Y 、磷脂酰肌醇 3-激酶、Akt 和 AS160 的激活，以频率依赖的方式通过连接蛋白 1 通道从肌纤维中释放三磷酸腺苷（ATP）；细胞外 ATP 激活信号，最终调节基因表达，并能够通过激活增加葡萄糖转运。我们假设，这种机制是运动与肌纤维可塑性和代谢调节之间的重要联系。
