混杂孕育多样性：聚酮合酶在天然产物生物合成中的作用
Promiscuity breeds diversity: the role of polyketide synthase in natural product biosynthesis.
作者信息
Fischer Reinhard
机构信息
Department of Microbiology, Institute for Applied Biosciences, Karlsruhe Institute of Technology (KIT)-South Campus, Hertzstrasse 16, 76187 Karlsruhe, Germany.
出版信息
Chem Biol. 2014 Jun 19;21(6):701-2. doi: 10.1016/j.chembiol.2014.05.011.
Abstract
Secondary metabolites are often highly biologically active molecules and are widely used from antibacterial to anticancer drugs. In this issue of Chemistry and Biology, Zaehle and coworkers describe the gene cluster and biosynthesis of the polyketide terrein, a secondary metabolite produced by the soil-borne fungus Aspergillus terreus.
摘要
次生代谢产物通常是具有高度生物活性的分子，广泛应用于从抗菌药物到抗癌药物等领域。在本期《化学与生物学》中，扎勒及其同事描述了聚酮化合物土曲霉毒素的基因簇和生物合成过程，土曲霉毒素是一种由土壤真菌土曲霉产生的次生代谢产物。
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