Lynch M R, Carey R J
S.U.N.Y. Health Science Center, Department of Psychiatry, Syracuse 13210.
Behav Brain Res. 1989 Feb 1;32(1):69-74. doi: 10.1016/s0166-4328(89)80073-7.
Early postlesion amphetamine-induced contralateral rotation has been linked to intraneuronal dopamine (DA) accumulation and transmitter release associated with axonal degeneration. Animals in the present study sustained severe unilateral depletion of striatal DA with or without a near-complete loss of ipsilateral mesolimbic DA. Contralateral rotation to 1.0 mg/kg (+)-amphetamine was observed on days 1 and 4 postlesion, and was greatly enhanced in mesolimbic-lesioned animals on day 4. On days 7 and 14, very little contralateral turning was observed and there was an emergence of low-rate ipsilateral rotation. These changes in direction and magnitude of rotational response suggest neurochemical adaptations which continue beyond initial periods of intraneuronal accumulation and degeneration-induced release.
损伤后早期苯丙胺诱导的对侧旋转与轴突退变相关的神经元内多巴胺（DA）积累及递质释放有关。本研究中的动物纹状体DA出现严重单侧耗竭，伴或不伴有同侧中脑边缘DA几乎完全丧失。损伤后第1天和第4天观察到对1.0 mg/kg（+）-苯丙胺的对侧旋转，且在第4天中脑边缘损伤的动物中大大增强。在第7天和第14天，观察到极少的对侧转动，且出现低频率的同侧旋转。旋转反应方向和幅度的这些变化表明神经化学适应在神经元内积累和退变诱导释放的初始阶段之后仍持续存在。
