心脏移植及心肺联合移植后对动态运动的心肺反应
Cardiopulmonary response to dynamic exercise after heart and combined heart-lung transplantation.
作者信息
Banner N R, Lloyd M H, Hamilton R D, Innes J A, Guz A, Yacoub M H
机构信息
Cardiothoracic Unit, Harefield Hospital, Middlesex.
出版信息
Br Heart J. 1989 Mar;61(3):215-23. doi: 10.1136/hrt.61.3.215.
The exercise capacity and cardiopulmonary response to progressive dynamic exercise of eight healthy recipients of heart-lung transplants were compared with those of matched recipients of orthotopic cardiac transplants and normal controls. In both transplant groups the maximum workloads were lower than that in the normal group. The transplant recipients had higher pre-exercise heart rates and lower maximum heart rates than the normal controls. Ventilation during submaximal exercise was similar in the heart transplant group and the controls. The heart-lung group had an increased ventilatory response associated with lower end tidal carbon dioxide concentrations. Exercise capacity after combined heart-lung transplantation is similar to that after cardiac transplantation. Transplant recipients have an abnormal heart rate response during exercise related to cardiac denervation. The altered ventilatory response in heart-lung recipients may be the result of pulmonary denervation.
将8名健康心肺移植受者的运动能力及心肺对递增动态运动的反应，与匹配的原位心脏移植受者及正常对照组进行了比较。在两个移植组中，最大工作量均低于正常组。移植受者运动前心率高于正常对照组，最大心率低于正常对照组。心脏移植组与对照组在次最大运动量时的通气情况相似。心肺移植组的通气反应增强，同时呼气末二氧化碳浓度降低。心肺联合移植后的运动能力与心脏移植后相似。移植受者在运动期间存在与心脏去神经支配相关的异常心率反应。心肺移植受者通气反应的改变可能是肺去神经支配的结果。
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