Matanović Maja Radivojša, Kristl Julijana, Grabnar Pegi Ahlin
University of Ljubljana, Faculty of Pharmacy, Aškerčeva 7, Ljubljana 1000, Slovenia.
University of Ljubljana, Faculty of Pharmacy, Aškerčeva 7, Ljubljana 1000, Slovenia.
Int J Pharm. 2014 Sep 10;472(1-2):262-75. doi: 10.1016/j.ijpharm.2014.06.029. Epub 2014 Jun 17.
Thermally induced gelling systems have gained enormous attention over the last decade. They consist of hydrophilic homopolymers or block copolymers in water that present a sol at room temperature and form a gel after administration into the body. This article reviews the main types of thermoresponsive polymers, with special focus on decisive hydrogel characteristics, mechanisms of gelation, and biocompatibility. Promising biomedical applications are described with a focus on injectable formulations, which include solubilization of small hydrophobic drugs, controlled release, delivery of labile biopharmaceutics, such as proteins and genes, cell encapsulation, and tissue regeneration. Furthermore, combinations of thermoresponsive hydrogels and various nanocarriers as promising systems for sustained drug delivery are discussed through selected examples from the literature. Finally, there is a brief overview of current progress in nano-sized systems incorporating thermoresponsive properties.
在过去十年中，热致凝胶系统受到了极大的关注。它们由水中的亲水性均聚物或嵌段共聚物组成，在室温下呈溶胶状态，注入体内后形成凝胶。本文综述了主要类型的热响应性聚合物，特别关注决定性的水凝胶特性、凝胶化机制和生物相容性。文中描述了有前景的生物医学应用，重点是可注射制剂，包括小疏水药物的增溶、控释、不稳定生物药物（如蛋白质和基因）的递送、细胞封装和组织再生。此外，通过文献中的选定实例，讨论了热响应性水凝胶与各种纳米载体的组合作为有前景的持续药物递送系统。最后，简要概述了具有热响应特性的纳米系统的当前进展。
