Rumon Md Mahamudul Hasan, Akib Anwarul Azim, Sarkar Stephen Don, Khan Md Abu Rayhan, Uddin Md Mosfeq, Nasrin Dina, Roy Chanchal Kumar
Department of Chemistry, Bangladesh University of Engineering and Technology, Dhaka 1000, Bangladesh.
Department of Chemistry, University of Houston, Houston, Texas 77204, United States.
ACS Polym Au. 2024 Aug 20;4(6):463-486. doi: 10.1021/acspolymersau.4c00028. eCollection 2024 Dec 11.
In recent years, numerous applications of hydrogels using polysaccharides have evolved, benefiting from their widespread availability, excellent biodegradability, biocompatibility, and nonpoisonous nature. These natural polymers are typically sourced from renewable materials or from manufacturing processes, contributing collaboratively to waste management and demonstrating the potential for enhanced and enduring sustainability. In the field of novel bioactive molecule carriers for biotherapeutics, natural polymers are attracting attention due to their inherent properties and adaptable chemical structures. These polymers offer versatile matrices with a range of architectures and mechanical properties, while retaining the bioactivity of incorporated biomolecules. However, conventional polysaccharide-based hydrogels suffer from inadequate mechanical toughness with large swelling properties, which prohibit their efficacy in real-world applications. This review offers insights into the latest advancements in the development of diverse polysaccharide-based hydrogels for biotherapeutic administrations, either standalone or in conjunction with other polymers or drug delivery systems, in the pharmaceutical and biomedical fields.
近年来，利用多糖的水凝胶的众多应用不断发展，这得益于其广泛的可得性、出色的生物降解性、生物相容性和无毒性质。这些天然聚合物通常来源于可再生材料或制造过程，共同为废物管理做出贡献，并展现出增强和持久可持续性的潜力。在用于生物治疗的新型生物活性分子载体领域，天然聚合物因其固有特性和可适应的化学结构而备受关注。这些聚合物提供了具有多种结构和机械性能的通用基质，同时保留了所掺入生物分子的生物活性。然而，传统的基于多糖的水凝胶机械韧性不足且溶胀性大，这限制了它们在实际应用中的效果。本综述深入探讨了在制药和生物医学领域中，用于生物治疗给药的各种基于多糖的水凝胶的最新进展，这些水凝胶既可以单独使用，也可以与其他聚合物或药物递送系统联合使用。
