Pimentel Gustavo D, Ganeshan Kirthana, Carvalheira José B C
Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Cardiovascular Research Institute, University of California, San Francisco, CA 94158-9001, United States.
Mol Cell Endocrinol. 2014 Nov;397(1-2):15-22. doi: 10.1016/j.mce.2014.06.005. Epub 2014 Jun 18.
The control of energy homeostasis relies on robust neuronal circuits that regulate food intake and energy expenditure. Although the physiology of these circuits is well understood, the molecular and cellular response of this program to chronic diseases is still largely unclear. Hypothalamic inflammation has emerged as a major driver of energy homeostasis dysfunction in both obesity and anorexia. Importantly, this inflammation disrupts the action of metabolic signals promoting anabolism or supporting catabolism. In this review, we address the evidence that favors hypothalamic inflammation as a factor that resets energy homeostasis in pathological states.
能量稳态的控制依赖于调节食物摄入和能量消耗的强大神经回路。尽管这些回路的生理学机制已为人熟知，但该程序对慢性疾病的分子和细胞反应仍不清楚。下丘脑炎症已成为肥胖症和厌食症中能量稳态功能障碍的主要驱动因素。重要的是，这种炎症会破坏促进合成代谢或支持分解代谢的代谢信号的作用。在这篇综述中，我们阐述了支持下丘脑炎症作为病理状态下重置能量稳态的一个因素的证据。
