Shinde Suvarna, Kabra Nandkishor S, Sharma Shobha R, Avasthi Bhupendra S, Ahmed Javed
Department of Neonatology, Surya Childrens Hospital, Santacruz West, Mumbai, India. Correspondence to: Dr Nandkishor S Kabra, Department of Neonatology, Surya Childrens Hospital, Mangal Ashirwad, Junction of S V Road and Dattatraya Road, Santacruz West, Mumbai 400054 India.
Indian Pediatr. 2014 May;51(5):367-70. doi: 10.1007/s13312-014-0418-8.
To compare the efficacy of glycerin suppository versus no suppository in preterm very-low-birthweight neonates for improving feeding tolerance.
Randomized controlled trial.
Level III neonatal unit from Mumbai, India.
50 very-low-birthweight (birth weight between 1000 to 1500 grams)preterm (gestational age between 28 to 32 weeks) neonates randomized to glycerine suppository (n=25) or no intervention (n=26).
Glycerin suppository (1g) once a day from day-2 to day-14 of life or no suppository, along with intermittent oral feeds and standardized care.
Time required to achieve full enteral feeds (180 mL/kg/d).
Baseline characteristics of neonates like gestational age, birthweight, gender and age at the time of introduction of feeds were comparable in both groups. The mean (SD) duration to reach full enteral feed was 11.90 (3.1) days in glycerin suppository group and was not significantly different (P=0.58) from control group, [11.33 (3.57) days]. Glycerin suppository group regained birth weight 2 days earlier than control group but this difference was not significant (P=0.16). There was no significant difference in duration of hospital stay or occurrence of necrotizing enterocolitis amongst the two study groups.
Once daily application of glycerin suppository does not accelerate the achievement of full feeds in preterm very-low-birthweight neonates.
比较甘油栓与不使用栓剂对改善极低出生体重早产儿喂养耐受性的疗效。
随机对照试验。
印度孟买的三级新生儿病房。
50例极低出生体重（出生体重在1000至1500克之间）的早产儿（胎龄在28至32周之间），随机分为甘油栓组（n = 25）或无干预组（n = 26）。
从出生第2天至第14天每天使用一次甘油栓（1克）或不使用栓剂，同时进行间歇性口服喂养和标准化护理。
达到完全肠内喂养（180毫升/千克/天）所需的时间。
两组新生儿的基线特征，如胎龄、出生体重、性别和开始喂养时的年龄具有可比性。甘油栓组达到完全肠内喂养的平均（标准差）持续时间为11.90（3.1）天，与对照组[11.33（3.57）天]相比无显著差异（P = 0.58）。甘油栓组比对照组早2天恢复出生体重，但差异不显著（P = 0.16）。两个研究组在住院时间或坏死性小肠结肠炎的发生率方面无显著差异。
对于极低出生体重的早产儿，每天使用一次甘油栓并不能加速完全喂养的实现。
