Shruthi T K, Shuba S, Rajakumar P S, Chitrambalam S
Departments of Pediatrics and *Neurology, Sri Ramachandra Medical College, Chennai, Tamil Nadu, India. Correspondence to: Dr TK Shruthi, Assistant Professor, Department of Pediatrics, SRMC and RI, Porur, Chennai 600 116, India.
Indian Pediatr. 2014 May;51(5):405-6.
Anti N-methyl-D-aspartate (NMDA) receptor encephalitis is an immune mediated disorder.
A previously healthy 14-year-old girl presenting with generalized tonic clonic seizures and altered behavior.
In view of refractory seizures, hallucinations, psychobehavioral and catalepsy like symptoms, and CSF showing lymphocytic pleocytosis, possibility of autoimmune encephalitis was considered. Serum was positive for anti-NMDA receptor antibodies.
She recovered completely in six months without any sequelae.
Anti-NMDA receptor encephalitis - a potentially treatable disease - should be considered in differential diagnosis of encephalitis when acute behavioral changes, seizures or dyskinesias are present.
抗N-甲基-D-天冬氨酸（NMDA）受体脑炎是一种免疫介导的疾病。
一名既往健康的14岁女孩，出现全身性强直阵挛发作和行为改变。
鉴于难治性癫痫发作、幻觉、精神行为及类僵住症症状，且脑脊液显示淋巴细胞增多，考虑自身免疫性脑炎的可能性。血清抗NMDA受体抗体呈阳性。
她在6个月内完全康复，无任何后遗症。
当出现急性行为改变、癫痫发作或运动障碍时，抗NMDA受体脑炎（一种潜在可治疗的疾病）应列入脑炎的鉴别诊断中。
