Gallego A, Rogel R, Luján S, Plaza B, Delgado F, Boronat F
Servicio de Urología, Hospital Universitari i Politècnic La Fe, Valencia, España.
Servicio de Urología, Hospital Universitari i Politècnic La Fe, Valencia, España.
Actas Urol Esp. 2014 Dec;38(10):698-702. doi: 10.1016/j.acuro.2014.04.003. Epub 2014 Jun 19.
Aproximately 10% of patients with non-obstructive azoospermia and 5% with non-obstructive severe oligozoospermia carry AZF region microdeletions (AZoospermic Factor) in the Y chromosome. The aim of this study is to analize the clinical and pathological findings in this group of patients and compare them with the previous evidence.
Retrospective study of 11 patients with diagnosis of azoospermia or oligozoospermia and the presence of AZFa, AZFb, AZFc microdeletions or any combination of them.
Microdeletions of AZFc region were found in 45% of cases, AZFa in 33% and a 10% showed a deletion of the three regions (a,b and c). 91% of them demonstrated azoospermia with low testicular volume in 62,5% cases.
Microdeletions of AZF regions are associated with azoospermia and a low expectation of sperm retrieval in testicular biopsy. On the other hand, they seem not related with significative modifications on the hormone profile.
约10%的非梗阻性无精子症患者和5%的非梗阻性严重少精子症患者存在Y染色体AZF区域微缺失（无精子症因子）。本研究的目的是分析该组患者的临床和病理表现，并与先前的证据进行比较。
对11例诊断为无精子症或少精子症且存在AZFa、AZFb、AZFc微缺失或其任意组合的患者进行回顾性研究。
45%的病例发现AZFc区域微缺失，33%发现AZFa微缺失，10%显示三个区域（a、b和c）均有缺失。其中91%表现为无精子症，62.5%的病例睾丸体积较小。
AZF区域微缺失与无精子症以及睾丸活检中精子获取的低期望相关。另一方面，它们似乎与激素水平的显著改变无关。
