Rajabbik Mhd Hashem, Lotfi Tamara, Alkhaled Lina, Fares Munes, El-Hajj Fuleihan Ghada, Mroueh Salman, Akl Elie A
Clinical Research Institute, American University of Beirut, Beirut, Lebanon.
Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
Allergy Asthma Clin Immunol. 2014 Jun 11;10(1):31. doi: 10.1186/1710-1492-10-31. eCollection 2014.
There is conflicting evidence about the association between low vitamin D levels in children and development of asthma in later life. The objective of this study was to systematically review the evidence for an epidemiological association between low serum levels of vitamin D and the diagnosis of asthma in children.
We used the Cochrane methodology for conducting systematic reviews. The search strategy included an electronic search of MEDLINE and EMBASE in February 2013. Two reviewers completed, in duplicate and independently, study selection, data abstraction, and assessment of risk of bias.
Of 1081 identified citations, three cohort studies met eligibility criteria. Two studies found that low serum vitamin D level is associated with an increased risk of developing asthma late in childhood, while the third study found no association with either vitamin D2 or vitamin D3 levels. All three studies suffer from major methodological shortcomings that limit our confidence in their results.
Available epidemiological evidence suggests a potential association between low serum levels of vitamin D and the diagnosis of asthma in children. High quality studies are needed to reliably answer the question of interest.
关于儿童维生素D水平低与日后患哮喘之间的关联，证据存在冲突。本研究的目的是系统回顾血清维生素D水平低与儿童哮喘诊断之间的流行病学关联证据。
我们采用Cochrane方法进行系统评价。检索策略包括2013年2月对MEDLINE和EMBASE进行电子检索。两名评价员独立、重复地完成研究选择、数据提取和偏倚风险评估。
在1081条检索到的文献中，三项队列研究符合纳入标准。两项研究发现血清维生素D水平低与儿童后期患哮喘风险增加有关，而第三项研究未发现与维生素D2或维生素D3水平有关联。所有三项研究都存在重大方法学缺陷，这限制了我们对其结果的信心。
现有流行病学证据表明血清维生素D水平低与儿童哮喘诊断之间可能存在关联。需要高质量的研究来可靠地回答感兴趣的问题。
