Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, 901 87 Umeå, Sweden.
Department of Clinical Microbiology/Clinical Immunology, Umeå University, 901 87 Umeå, Sweden.
J Immunol Res. 2014;2014:696415. doi: 10.1155/2014/696415. Epub 2014 May 14.
To analyse levels of S100A8/S100A9 (calprotectin) and selected cytokines, in blood, in patients with psoriatic arthritis (PsA).
Sixty-five patients with PsA were examined for clinical manifestations and laboratory measurements of S-calprotectin, ESR, hs-CRP, and selected cytokines. Thirty-two patients had mono-/oligoarthritis and 33 had polyarthritis. S-calprotectin, hs-CRP, and cytokines were measured using ELISA, immunoturbidimetry, and multiplex technology (Bio-Plex). Patients with PsA were compared with 31 healthy controls.
S-calprotectin and hs-CRP levels were significantly higher in patients with PsA compared with controls (P<0.001 and P<0.001, resp.). Patients suffering a polyarthritic disease pattern presented with significantly higher levels of S-calprotectin compared with controls and patients with mono-/oligoarthritis (P<0.001 and P=0.017, resp.). The levels of S-calprotectin correlated with hs-CRP (P<0.001; rs=0.441), swollen joint count (P=0.002, rs=0.397), and CXCL10 (P=0.046, rs=0.678) but not with any of the other cytokines evaluated. In multiple logistic regression analysis, S-calprotectin was the only variable significantly associated with psoriatic arthritis (P=0.002, OR=1.006, 95% CI=1.002-1.010).
S-calprotectin and hs-CRP levels were significantly higher in patients with PsA. A polyarthritic disease pattern showed higher levels of S-calprotectin than mono-/oligoarthritis. S-calprotectin is considered a potential marker of disease activity in patients with PsA.
分析银屑病关节炎（PsA）患者血液中 S100A8/S100A9（钙卫蛋白）和选定细胞因子的水平。
对 65 例 PsA 患者进行临床症状和 S-钙卫蛋白、ESR、hs-CRP 和选定细胞因子的实验室检测。32 例患者为单关节炎/寡关节炎，33 例为多关节炎。采用 ELISA、免疫比浊法和多重技术（Bio-Plex）检测 S-钙卫蛋白、hs-CRP 和细胞因子。将 PsA 患者与 31 名健康对照者进行比较。
与对照组相比，PsA 患者的 S-钙卫蛋白和 hs-CRP 水平显著升高（P<0.001 和 P<0.001）。多关节炎患者的 S-钙卫蛋白水平显著高于对照组和单关节炎/寡关节炎患者（P<0.001 和 P=0.017）。S-钙卫蛋白水平与 hs-CRP（P<0.001；rs=0.441）、肿胀关节数（P=0.002，rs=0.397）和 CXCL10（P=0.046，rs=0.678）呈显著相关，但与其他评估的细胞因子均无相关性。在多元逻辑回归分析中，S-钙卫蛋白是唯一与银屑病关节炎显著相关的变量（P=0.002，OR=1.006，95%CI=1.002-1.010）。
PsA 患者的 S-钙卫蛋白和 hs-CRP 水平显著升高。多关节炎患者的 S-钙卫蛋白水平高于单关节炎/寡关节炎患者。S-钙卫蛋白被认为是 PsA 患者疾病活动的潜在标志物。
