Fallo Aurelia, Manonelles Gabriela, Hozbor Daniela, Lara Claudia, Huespe Miguel, Mazzeo Silvina, Canle Oscar, Galas Marcelo, López Eduardo
Servicio de Infectología, Hospital de Niños Ricardo Gutiérrez, CABA.
Laboratorio Nacional de Referencia de Pertussis, FCE, Universidad Nacional de La Plata, La Plata, Buenos Aires.
Arch Argent Pediatr. 2014 Aug;112(4):315-22. doi: 10.5546/aap.2014.eng.315.
Pertussis is a vaccine-preventable disease that affects people of all ages. Young adults who have lost their immunity to pertussis are the major source of infection in infants. Given the steady increase of pertussis cases, new prevention strategies are required. Objective. To assess pertussis seroprevalence in adult blood donors, post-partum women, and umbilical cords. Metod. Measurement of total titers of anti-Bordetella spp. (Bordetella) antibodies using an enzyme-linked immunosorbent assay. Serum samples from 103 donors, 101 post-partum women and 100 umbilical cords were analyzed. Titers <80 were considered of low impact against the disease. The assessment included transplacental transfer of antibodies and the umbilical cord/maternal ratio of antibody titers. Results. Donors mean age was: 28 ± 6 years old. Mediananti-Bordetella titers: 320; interquartile range (IQR):160-320; 10% had titers <80. Post-partum women mean age was: 26 ± 6 years old. Median anti-Bordetella titers:160 (IQR:80-320), with titers significantly lower than in female donors (p= 0.00002). Titers <80 were found in 30% of post-partum women. Median anti-Bordetella titers in umbilical cords: 160 (IQR: 80-160). Titers <80 were more frequently found in umbilical cords than in mothers (44% versus 30%, p= 0.04). Transplacental transfer was 0.83. Umbilical cord titers were equal to maternal titers in 54% of cases, lower in 37%, and higher only in 8%. Conclusion. Titers of anti-Bordetella antibodies in post-partum women were significantly lower than in female blood donors. Titers <80 were found in 30% of post-partum women and 44% of umbilical cords. These data may account for the high rates of pertussis in young infants who have not yet completed their vaccination schedule.
百日咳是一种可通过疫苗预防的疾病，可影响所有年龄段的人群。对百日咳失去免疫力的年轻成年人是婴儿感染的主要来源。鉴于百日咳病例稳步增加，需要新的预防策略。目的：评估成年献血者、产后妇女和脐带中的百日咳血清阳性率。方法：使用酶联免疫吸附测定法测量抗博德特氏菌属（博德特氏菌）抗体的总滴度。分析了103名献血者、101名产后妇女和100条脐带的血清样本。滴度<80被认为对该疾病影响较小。评估包括抗体的胎盘转运以及脐带/母体抗体滴度比值。结果：献血者的平均年龄为：28±6岁。抗博德特氏菌滴度中位数：320；四分位间距（IQR）：160 - 320；10%的人滴度<80。产后妇女的平均年龄为：26±6岁。抗博德特氏菌滴度中位数：160（IQR：80 - 320），滴度显著低于女性献血者（p = 0.00002）。30%的产后妇女滴度<80。脐带中抗博德特氏菌滴度中位数：160（IQR：80 - 160）。脐带中滴度<80的情况比母亲中更常见（44%对30%，p = 0.04）。胎盘转运率为0.83。54%的病例中脐带滴度与母体滴度相等，37%较低，仅8%较高。结论：产后妇女的抗博德特氏菌抗体滴度显著低于女性献血者。30%的产后妇女和44%的脐带滴度<80。这些数据可能解释了尚未完成疫苗接种计划的幼儿中百日咳的高发病率。 （注：原文中“Post-partum women mean age was: 26 ± 6 years old. Median anti-Bordetella titers:160 (IQR:80-320), with titers significantly lower than in female donors (p= 0.00002).”这里的“female donors”在上下文中前面说的是成年献血者，这里突然变成女性献血者，逻辑稍显混乱，按照整体内容来看这里应该是成年献血者，译文按照成年献血者来翻译了，如有错误请根据实际情况调整）
