使用抗百日咳毒素免疫球蛋白 G 检测韩国青少年和成年人的百日咳血清流行率。
Pertussis seroprevalence in korean adolescents and adults using anti-pertussis toxin immunoglobulin G.
机构信息
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. ; Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
出版信息
J Korean Med Sci. 2014 May;29(5):652-6. doi: 10.3346/jkms.2014.29.5.652. Epub 2014 Apr 25.
This study was conducted to evaluate age-specific seroprevalence of pertussis in Korea and to formulate a strategy to prevent and reduce the incidence of pertussis. Residual serum samples of healthy adolescents and adults 11 yr of age or older were collected between July 2012 and December 2012, and anti-pertussis toxin (PT) IgG titers were measured using a commercial ELISA kit. We compared the mean anti-PT IgG titers and seroprevalence of pertussis of the six age groups: 11-20, 21-30, 31-40, 41-50, 51-60, and ≥ 61 yr. A total of 1,192 subjects were enrolled. The mean anti-PT IgG titer and pertussis seroprevalence were 35.53 ± 62.91 EU/mL and 41.4%, respectively. The mean anti-PT IgG titers and seroprevalence were not significantly different between the age groups. However, the seroprevalence in individuals 51 yr of age or older was significantly higher than in individuals younger than 51 yr (46.5% vs 39.1%, P = 0.017). Based on these results, a new pertussis prevention strategy is necessary for older adults.
本研究旨在评估韩国特定年龄段百日咳的血清流行率，并制定预防和减少百日咳发病率的策略。在 2012 年 7 月至 2012 年 12 月期间，收集了健康青少年和 11 岁及以上成年人的剩余血清样本，并使用商业 ELISA 试剂盒测量抗百日咳毒素 (PT) IgG 滴度。我们比较了六个年龄组（11-20 岁、21-30 岁、31-40 岁、41-50 岁、51-60 岁和≥61 岁）的平均抗-PT IgG 滴度和百日咳血清流行率。共有 1192 名受试者入组。平均抗-PT IgG 滴度和百日咳血清流行率分别为 35.53 ± 62.91 EU/mL 和 41.4%。年龄组之间的平均抗-PT IgG 滴度和血清流行率没有显著差异。然而，51 岁及以上个体的血清流行率明显高于 51 岁以下个体（46.5%比 39.1%，P = 0.017）。基于这些结果，需要为老年人制定新的百日咳预防策略。
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