Lellig K, Beyer B, Graefen M, Zaak D, Stief C
Urologische Klinik und Poliklinik, Klinikum Großhadern, Marchioninistr. 15, 81377, München, Deutschland,
Urologe A. 2014 Jul;53(7):1031-9. doi: 10.1007/s00120-014-3535-z.
In Europe prostate cancer is one of the most common cancers among men. The diagnostics always include a control of the prostate-specific antigen (PSA) level and examination of a representative tissue sample from the prostate. With these findings it is possible to evaluate the degree of progression of the cancer and its prognosis. Several treatment options for localized prostate cancer are given by national and international guidelines including radical prostatectomy, percutaneous radiation therapy, or brachytherapy and surveillance of the cancer with optional treatment at a later stage. For the latter treatment option, known as active surveillance, strict criteria have to be met. The advantage of active surveillance is that only patients with progressive cancer are subjected to radical therapy. Patients with very slow or non-progressing cancer do not have to undergo therapy and thus do not have to suffer from the side effects. The basic idea behind active surveillance is that some cancers will not progress to a stage that requires treatment within the lifetime of the patient and therefore do not require treatment at all. Unfortunately the criteria for active surveillance are not definitive enough at the current time leading only to a delay in effective treatment for many patients. The surveillance strategy has without doubt a high significance among the treatment options for prostate cancer; however, at the current time it lacks reliable indicators for a certain prognosis. Therefore, patients must be informed in detail about the advantages and disadvantages of active surveillance.
在欧洲,前列腺癌是男性中最常见的癌症之一。诊断通常包括检测前列腺特异性抗原(PSA)水平以及检查前列腺的代表性组织样本。根据这些检查结果,可以评估癌症的进展程度及其预后。国家和国际指南给出了几种针对局限性前列腺癌的治疗方案,包括根治性前列腺切除术、经皮放射治疗、近距离放射治疗,以及在后期进行选择性治疗的癌症监测。对于后一种治疗方案,即所谓的主动监测,必须满足严格的标准。主动监测的优势在于只有癌症进展的患者才会接受根治性治疗。癌症进展非常缓慢或无进展的患者无需接受治疗,因此也不必承受副作用。主动监测背后的基本理念是,有些癌症在患者的一生中不会进展到需要治疗的阶段,因此根本不需要治疗。不幸的是,目前主动监测的标准还不够明确,这导致许多患者的有效治疗被延误。在前列腺癌的治疗方案中,监测策略无疑具有重要意义;然而,目前它缺乏用于确定预后的可靠指标。因此,必须向患者详细告知主动监测的利弊。