Department of Enfermería 1, Universidad del País Vasco UPV/EHU, Bilbao, Spain.
Expert Rev Vaccines. 2014 Aug;13(8):1001-12. doi: 10.1586/14760584.2014.932253. Epub 2014 Jun 24.
Superficial candidiasis of the oral cavity, vagina and the skin are common mild infections though they may be recalcitrant, as in the case of recurrent vaginitis or denture stomatitis. However, in debilitated people with immune deficiencies, Candida can cause serious invasive infections with high mortality. Both types of patients could benefit from the development of vaccines and monoclonal or polyclonal antibodies of utility for a passive immunization, according to their immune status. Several antigens as mannans, β-glucans, various adhesins, heat shock protein 90 and acid secreted proteinases can be very useful for the vaccines development. There is a broad and sound experience with many of these antigens in animal models, mainly in rabbits and mice. However, only two vaccines, based on recombinant antigens (rAls3p-N and rSap2t) are currently being tested in clinical trials.
口腔、阴道和皮肤的浅部假丝酵母菌病虽然可能反复发作，如复发性阴道炎或义齿性口炎，但通常为轻度感染。然而，在免疫缺陷的虚弱人群中，假丝酵母菌可能导致严重的侵袭性感染，死亡率很高。根据免疫状态，这两种类型的患者都可以从疫苗和单克隆或多克隆抗体的开发中受益，这些抗体可用于被动免疫。甘露聚糖、β-葡聚糖、各种黏附素、热休克蛋白 90 和酸性分泌蛋白酶等几种抗原对疫苗的开发非常有用。在动物模型中，这些抗原中的许多抗原都有广泛而良好的经验，主要是在兔子和老鼠中。然而，目前只有两种基于重组抗原（rAls3p-N 和 rSap2t）的疫苗正在临床试验中进行测试。
