Raviv Gil, Laufer Menachem, Baruch Yehuda, Barak Yoram
Department of Urology, Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel-Aviv University, Israel.
Abarbanel Mental Health Center, Bat-Yam, Israel; Sackler School of Medicine, Tel-Aviv University, Israel.
Compr Psychiatry. 2014 Oct;55(7):1639-42. doi: 10.1016/j.comppsych.2014.05.007. Epub 2014 May 17.
To examine the rate of prostate cancer in a cohort of schizophrenia in-patients in the PSA-era as compared to expected rates. There is conflicting evidence on the relative risk of prostate cancer in men with schizophrenia.
the study sample was comprised of schizophrenia patients who had been admitted to a tertiary care mental health center between 1990 and 2011. The data for the sample was cross-referenced with the National Cancer Registry. Analyses of Standardized Incidence Rates (SIR) for prostate cancer and for lung cancer (representing an organ system not sensitive to sex hormones) were performed.
Of 4,326 schizophrenia patients included in the present study, 181 (4.2%) were diagnosed with cancer at any site. Only 10 of these patients were diagnosed with prostate cancer. This reflects a reduced risk; SIR of 0.56 (95% CI 0.27-1.03). In the same cohort, 33 schizophrenia patients were diagnosed with lung cancer presenting a SIR of 1.43 (95% CI 0.98-2.01) in this sample.
The present study suggests a reduced rate of prostate cancer in patients admitted for schizophrenia. There are several possible explanations for this finding including chronic state of hyperprolactinemia induced by antipsychotic drugs.
在前列腺特异性抗原（PSA）时代，研究一组精神分裂症住院患者的前列腺癌发病率，并与预期发病率进行比较。关于精神分裂症男性患前列腺癌的相对风险，证据存在冲突。
研究样本包括1990年至2011年间入住三级精神卫生保健中心的精神分裂症患者。样本数据与国家癌症登记处进行交叉核对。对前列腺癌和肺癌（代表一个对性激素不敏感的器官系统）的标准化发病率（SIR）进行分析。
在本研究纳入的4326例精神分裂症患者中，181例（4.2%）在任何部位被诊断出患有癌症。其中只有10例患者被诊断出患有前列腺癌。这反映出风险降低；标准化发病率为0.56（95%置信区间0.27 - 1.03）。在同一队列中，33例精神分裂症患者被诊断出患有肺癌，该样本中的标准化发病率为1.43（95%置信区间为0.98 - 2.01）。
本研究表明，因精神分裂症入院的患者前列腺癌发病率降低。这一发现有几种可能的解释，包括抗精神病药物引起的慢性高催乳素血症状态。
