Andrew D, Haavik H, Dancey E, Yielder P, Murphy B
University of Ontario Institute of Technology, Faculty of Health Sciences, 2000 Simcoe Street North, Oshawa, Ont. L1H 7K4, Canada.
New Zealand College of Chiropractic, Centre for Chiropractic Research, 6 Harrison Road Mt Wellington, P.O. Box 112-044 Newmarket, Auckland 1149, New Zealand.
Clin Neurophysiol. 2015 Mar;126(3):575-80. doi: 10.1016/j.clinph.2014.05.020. Epub 2014 Jun 5.
Accumulating evidence indicates that plastic changes can be maladaptive in nature, resulting in movement and neurological disorders. The aim of this study was to further the understanding of these neurophysiological changes in sensorimotor integration (SMI) using somatosensory evoked potentials (SEPs) and concurrent performance changes following a repetitive typing task.
SEPs were recorded following median nerve stimulation at the wrist and performed pre and post intervention. 24 participants were randomly assigned to either an intervention group which performed a 20min repetitive typing task or a control group which participated in a 20min period of mental recitation.
The P22-N24 amplitude increased by 59.6%, compared to only 0.96% increase following the control. The P22-N30 SEP peak amplitude increased on average 13.4% following the motor training, compared to only 0.92% following the control. Significant improvement in reaction time when comparing performance of the motor task for the intervention group was observed.
The N24 increase supports the involvement of cerebellar connections and the N30 increase provides further support for changes in SMI following motor learning.
Combining motor training tasks with electrophysiological techniques gives insight into the mechanisms of disordered SMI and whether the changes are adaptive or maladaptive.
越来越多的证据表明，可塑性变化本质上可能是适应不良的，会导致运动和神经障碍。本研究的目的是通过体感诱发电位（SEP）以及重复打字任务后并发的性能变化，进一步了解感觉运动整合（SMI）中的这些神经生理变化。
在手腕处刺激正中神经后记录SEP，并在干预前后进行。24名参与者被随机分配到干预组（进行20分钟的重复打字任务）或对照组（进行20分钟的默念）。
与对照组仅增加0.96%相比，P22-N24波幅增加了59.6%。运动训练后，P22-N30 SEP峰波幅平均增加了13.4%，而对照组仅增加了0.92%。观察到干预组在运动任务表现方面的反应时间有显著改善。
N24波幅增加支持小脑连接的参与，N30波幅增加为运动学习后SMI的变化提供了进一步支持。
将运动训练任务与电生理技术相结合，有助于深入了解SMI紊乱的机制以及这些变化是适应性的还是适应不良的。
