Zefirov T L, Ziyatdinova N I, Khisamieva L I, Zefirov A L
Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia,
Bull Exp Biol Med. 2014 Jun;157(2):194-7. doi: 10.1007/s10517-014-2523-z. Epub 2014 Jun 24.
We studied the effect of α2-adrenoceptor stimulation with clonidine on BP and cardiac activity in rats. Variations in BP and chronotropism of the heart were studied in vivo after bolus injection of clonidine. In vitro experiments were performed to evaluate a dose-dependent change in myocardial contractility of the atria and ventricles after treatment with clonidine in concentrations of 10(-9)-10(-5) M. α2-Adrenoceptor stimulation with clonidine had a negative chronotropic and inotropic effect and induced the decrease in systolic BP of rats.
我们研究了可乐定刺激α2-肾上腺素能受体对大鼠血压和心脏活动的影响。在静脉推注可乐定后，在体内研究了血压和心脏变时性的变化。进行体外实验以评估用浓度为10（-9）-10（-5）M的可乐定处理后心房和心室心肌收缩力的剂量依赖性变化。可乐定刺激α2-肾上腺素能受体具有负性变时和变力作用，并导致大鼠收缩压降低。
