Ziyatdinova N I, Kuptsova A M, Faskhutdinov L I, Zefirov A L, Zefirov T L
Department of Human Health protection, Kazan (Volga Region) Federal University, Kazan, Republic of Tatarstan, Russia.
Department of Normal Physiology, Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Republic of Tatarstan, Russia.
Bull Exp Biol Med. 2018 Sep;165(5):593-596. doi: 10.1007/s10517-018-4220-9. Epub 2018 Sep 17.
We studied the effect of α-adrenoreceptor agonist clonidine hydrochloride in concentrations of 10-10 M on inotropy, chronotropy, and coronary flow in Langendorff-isolated heart of adult rats. It was found that α-adrenoreceptor agonist changed all studied parameters. Left ventricular myocardium contraction force decreased after application of all tested concentrations, the maximum effect was observed at a concentration of 10 M. Stimulation of α-adrenergic receptors in concentrations of 10, 10, and 10 M produced a two-phase effect (initial increase and a subsequent decrease) on the coronary flow. Clonidine hydrochloride in the maximum concentration (10 M) caused a decrease in HR in one group and an increase in the other.
我们研究了浓度为10⁻¹⁰ M的α-肾上腺素能受体激动剂盐酸可乐定对成年大鼠Langendorff离体心脏的心肌收缩力、心率和冠状动脉血流量的影响。结果发现，α-肾上腺素能受体激动剂改变了所有研究参数。在应用所有测试浓度后，左心室心肌收缩力均下降，在浓度为10⁻⁸ M时观察到最大效应。浓度为10⁻¹⁰ M、10⁻⁹ M和10⁻⁸ M的α-肾上腺素能受体刺激对冠状动脉血流量产生了双相效应（最初增加，随后减少）。最大浓度（10⁻⁸ M）的盐酸可乐定在一组中导致心率下降，而在另一组中导致心率增加。
