Khavinson V Kh, Lin'kova N S, Polyakova V O, Durnova A O, Nichik T E, Kvetnoi I M
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Bull Exp Biol Med. 2014 Jun;157(2):261-4. doi: 10.1007/s10517-014-2540-y. Epub 2014 Jun 24.
We studied the effect of polypeptide complex isolated from calf kidney and short peptides T-31 (AED) and T-35 (EDL) on the expression of signaling molecules, markers of cell renewal (Ki-67, p53), remodeling of the extracellular matrix (MMP-14), and immune response (IL-8) in primary kidney cell cultures during aging. The complex of renal polypeptides and T-31 peptide activate cell renewal processes during aging of the renal epithelium, while gelatinase MMP-14 is the target of T-35 peptide.
我们研究了从小牛肾脏分离出的多肽复合物以及短肽T-31（AED）和T-35（EDL）对衰老过程中原代肾细胞培养物中信号分子、细胞更新标志物（Ki-67、p53）、细胞外基质重塑（MMP-14）和免疫反应（IL-8）表达的影响。肾多肽和T-31肽的复合物在肾上皮衰老过程中激活细胞更新过程，而明胶酶MMP-14是T-35肽的作用靶点。
