Khavinson V Kh, Lin'kova N S, Evlashkina E V, Durnova A O, Kozlov K L, Gutop O E
St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
Bull Exp Biol Med. 2014 Nov;158(1):159-63. doi: 10.1007/s10517-014-2713-8. Epub 2014 Nov 19.
We studied molecular mechanisms of the vasoprotective effects of tripeptide T-38 and dipeptide RR-1. Short peptides T-38 and the RR-1 activate the processes of cell renewal in organotypic and dissociated cultures of vascular cells during aging by increasing the expression of Ki-67 and reducing the synthesis of p53 protein. T-38 and RR-1 reduce the synthesis of E-selectin, adhesion molecule involved in the formation of atherosclerotic plaques.
