Newby Brittney N, Terada Naohiro, Mathews Clayton E
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610-0275, USA.
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610-0275, USA.
Trends Endocrinol Metab. 2014 Aug;25(8):378-80. doi: 10.1016/j.tem.2014.05.006. Epub 2014 Jun 20.
Replacement of insulin-producing cells is a promising therapy for the restoration of the beta cell mass that is destroyed in patients with type 1 diabetes (T1D). However, the use of large amounts of islets per transplant, coupled with the scarcity of donor tissue, diminishes its feasibility. Here we briefly discuss current progress in developing ideal functional beta cells as well as the rationale for developing renewable sources of insulin-producing cells that can be transplanted.
替换产生胰岛素的细胞是一种很有前景的疗法，可用于恢复1型糖尿病（T1D）患者体内被破坏的β细胞数量。然而，每次移植使用大量胰岛，再加上供体组织稀缺，降低了其可行性。在此，我们简要讨论一下在开发理想的功能性β细胞方面的当前进展，以及开发可用于移植的可再生胰岛素产生细胞来源的基本原理。
