Prusch R D, Goette S M, Haberman P
Department of Life Sciences, Gonzaga University, Spokane, Washington 99258.
Cell Tissue Res. 1989 Mar;255(3):553-7. doi: 10.1007/BF00218790.
Phagocytosis in Amoeba proteus can be induced with prostaglandins (PG). In addition, arachidonic acid (the fatty acid precursor to the PG-2 series) also induces phagocytosis. The induction of phagocytosis with arachidonic acid can be partially inhibited by the cyclooxygenase inhibitor indomethacin. Phagocytosis in the amoeba can also be induced with the chemotactic peptide N-formylmethionyl-leucylphenylalanine (NFMLP). The peptide presumably induces phagocytosis by interacting with receptors on the amoeba surface, which may initiate the release of arachidonic acid from membrane lipids. NFMLP-induced phagocytosis can also be partially inhibited by indomethacin. It is suggested that PG's or biochemically related substances may play a signal-coupling role during phagocytosis in the amoeba.
变形虫中的吞噬作用可由前列腺素（PG）诱导。此外，花生四烯酸（PG - 2系列的脂肪酸前体）也能诱导吞噬作用。花生四烯酸诱导的吞噬作用可被环氧化酶抑制剂吲哚美辛部分抑制。变形虫中的吞噬作用也可由趋化肽N - 甲酰甲硫氨酰 - 亮氨酰 - 苯丙氨酸（NFMLP）诱导。该肽可能通过与变形虫表面的受体相互作用来诱导吞噬作用，这可能引发花生四烯酸从膜脂中释放。NFMLP诱导的吞噬作用也可被吲哚美辛部分抑制。有人提出，PG或与其生化相关的物质可能在变形虫的吞噬作用中发挥信号偶联作用。
