大鼠饮食中的亚麻酸减少了源自花生四烯酸的前列腺素的生成。

Decreased formation of porstaglandins derived from arachidonic acid by dietary linolenate in rats.

作者信息

Hwang D H, Carroll A E

出版信息

Am J Clin Nutr. 1980 Mar;33(3):590-7. doi: 10.1093/ajcn/33.3.590.

DOI:10.1093/ajcn/33.3.590

Abstract

Accumulated evidence now suggests that availability of precursor acid is an important factor controlling the biosynthesis of prostaglandins (PG's). Since linolenic acid inhibits the conversion of linoleic acid to arachidonic acid (PGE2, PGF2 alpha, and thromboxane A2 precursor), rats receiving more linolenic acid are expected to have less arachidonic acid and thus less PG's synthesized from arachidonic acid than those receiving linoleic acid alone. Essential fatty acid-deficient rats, induced by feeding hydrogenated coconut oil diet for 15 weeks, were divided into six groups and fed graded amounts of purified methyl linolenate for 6 weeks. Each group of rats except essential fatty acid-deficient group received the same amount of linoleate. The results showed that the level of arachidonic acid in serum lipids and serum concentrations of PG's synthesized from arachidonic acid by platelets decreased as the amount of dietary linolenate increased. This indicated that biosynthesis of PG's in platelets can be influenced by the availability of precursors, and thus it can be modified by the manipulation of dietary fatty acids.

摘要

目前积累的证据表明，前体酸的可利用性是控制前列腺素（PGs）生物合成的一个重要因素。由于亚麻酸会抑制亚油酸向花生四烯酸（PGE2、PGF2α和血栓素A2的前体）的转化，预计摄入较多亚麻酸的大鼠体内花生四烯酸的含量会低于仅摄入亚油酸的大鼠，因此由花生四烯酸合成的PGs也会更少。通过喂食氢化椰子油饮食15周诱导产生必需脂肪酸缺乏的大鼠被分为六组，并喂食不同剂量的纯化亚麻酸甲酯6周。除必需脂肪酸缺乏组外，每组大鼠摄入相同量的亚油酸酯。结果显示，随着膳食亚麻酸酯摄入量的增加，血清脂质中花生四烯酸的水平以及血小板由花生四烯酸合成的PGs的血清浓度均降低。这表明血小板中PGs的生物合成会受到前体可利用性的影响，因此可以通过控制膳食脂肪酸来改变。