Kubo T, Kihara M, Misu Y
Department of Pharmacology, Yokohama City University School of Medicine, Japan.
Clin Exp Hypertens A. 1989;11(2):233-41. doi: 10.3109/10641968909035339.
The contents of glutamate, gamma-aminobutyric acid (GABA), glycine, beta-alanine and taurine in brainstem regions responsible for blood pressure regulation, the rostral ventrolateral medulla (RVL), the nucleus tractus solitarii (NTS) and the caudal ventrolateral medulla (CVL) regions, were determined in spontaneously hypertensive rats (SHR) as compared with Wistar Kyoto rats. In SHR, the content of glutamate was increased in the RVL, NTS and CVL regions whereas GABA and beta-alanine contents were decreased in the RVL and all the regions studied, respectively. There was no difference between WKY and SHR in glycine and taurine contents in all the regions studied. These results provide evidence suggesting alterations of brainstem amino acid metabolism in SHR.
与Wistar Kyoto大鼠相比，测定了自发性高血压大鼠（SHR）中负责血压调节的脑干区域，即延髓头端腹外侧区（RVL）、孤束核（NTS）和延髓尾端腹外侧区（CVL）中谷氨酸、γ-氨基丁酸（GABA）、甘氨酸、β-丙氨酸和牛磺酸的含量。在SHR中，RVL、NTS和CVL区域的谷氨酸含量增加，而RVL以及所有研究区域的GABA和β-丙氨酸含量分别降低。在所有研究区域中，WKY和SHR的甘氨酸和牛磺酸含量没有差异。这些结果提供了证据，表明SHR中脑干氨基酸代谢发生了改变。
