Kihara M, Kubo T
Department of Pharmacology, Yokohama City University School of Medicine, Japan.
Arch Int Pharmacodyn Ther. 1989 May-Jun;299:86-97.
Concentrations of glutamate, gamma-aminobutyric acid (GABA), glycine, beta-alanine and taurine were measured in microdissected areas of the rostral ventrolateral medulla (RVL), nucleus tractus solitarii (NTS) and caudal ventrolateral medulla (CVL) of the rat, and the effects of hydralazine-induced hypotension on the concentrations of amino acids were examined. All five amino acids were ubiquitously present in these brainstem regions. Hydralazine-induced hypotension increased glutamate levels in the NTS and CVL regions, but decreased GABA levels in all the regions studied. The level of glycine was decreased in the RVL region after hydralazine. Hydralazine decreased beta-alanine levels in the NTS and CVL regions. Electrical stimulation of slices containing the RVL region decreased glutamate levels but increased GABA levels in tissues. These results are compatible with the hypothesis that glutamate and GABA systems in these brainstem areas are related to blood pressure regulation.
测定了大鼠延髓头端腹外侧区（RVL）、孤束核（NTS）和延髓尾端腹外侧区（CVL）显微切割区域中谷氨酸、γ-氨基丁酸（GABA）、甘氨酸、β-丙氨酸和牛磺酸的浓度，并研究了肼屈嗪诱导的低血压对氨基酸浓度的影响。所有这五种氨基酸在这些脑干区域均普遍存在。肼屈嗪诱导的低血压使NTS和CVL区域的谷氨酸水平升高，但使所有研究区域的GABA水平降低。肼屈嗪作用后，RVL区域的甘氨酸水平降低。肼屈嗪使NTS和CVL区域的β-丙氨酸水平降低。电刺激包含RVL区域的脑片可降低组织中的谷氨酸水平，但可升高GABA水平。这些结果与以下假设相符，即这些脑干区域中的谷氨酸和GABA系统与血压调节有关。
