Bagirath Pacha Venkat, Kumar Jogishetty Vijay, Arvind Uttara Dasharatha, Shailaja Gangula
Department of Oral and Maxillofacial Pathology, Panineeya Dental College, Hyderabad, Andhra Pradesh, India.
Department of Oral and Maxillofacial Surgery, Panineeya Dental College, Hyderabad, Andhra Pradesh, India.
J Oral Maxillofac Pathol. 2014 Jan;18(1):80-3. doi: 10.4103/0973-029X.131918.
Non-Hodgkin's lymphoma (NHL) is primarily a disorder of lymph nodes, when limited primarily to extranodal sites it is referred to as primary extranodal lymphoma and accounts for 24-48% of all cases of NHL. The development of peripheral T-cell lymphoma is poorly understood and is thought to be associated with effector T cells involving chromosomal translocations. It has been suggested by few authors that the continued increased risk for NHL among highly active antiretroviral therapy (HAART)-treated human immunodeficiency virus (HIV)-infected persons may be a reflection of incomplete immune reconstitution and possibly a chronic state of B-cell hyperactivation. Here, we present one such rare case of extranodal NHL in a known HIV patient.
非霍奇金淋巴瘤（NHL）主要是一种淋巴结疾病，当主要局限于结外部位时，它被称为原发性结外淋巴瘤，占所有NHL病例的24% - 48%。外周T细胞淋巴瘤的发病机制尚不清楚，被认为与涉及染色体易位的效应T细胞有关。少数作者提出，在接受高效抗逆转录病毒治疗（HAART）的人类免疫缺陷病毒（HIV）感染者中，NHL风险持续增加可能反映了免疫重建不完全，也可能是B细胞过度激活的慢性状态。在此，我们报告一例已知HIV患者发生的这种罕见的结外NHL病例。
