Singh Rohit, Shaik Shabana, Negi Bhupender Singh, Rajguru Jagadish Prasad, Patil Pankaj Bajirao, Parihar Anuj Singh, Sharma Uma
Lecturer, Department of Prosthodontics, Crown Bridge and Implantology, Patna Dental College and Hospital, Patna, Bihar, India.
Postgraduate Student, Department of Oral Medicine and Radiology, The Oxford Dental College, Bangalore, Karnataka, India.
J Family Med Prim Care. 2020 Apr 30;9(4):1834-1840. doi: 10.4103/jfmpc.jfmpc_1037_19. eCollection 2020 Apr.
Lymphomas constitute the third most common neoplasm in head and neck region arising from the lymphoreticular system. Malignant lymphomas are divided into Hodgkin's disease and non-Hodgkin's lymphoma (NHL). NHL comprises approximately 5% of head and neck malignancies and displays a wide range of appearances comparable with Hodgkin's disease. Hodgkin's and non-Hodgkin's lymphomas are seen in the head and neck region, but extranodal disease, with or without lymph node involvement, is more common among NHL patients. Extranodal involvement includes the areas such as Waldeyer's ring (i.e., the tonsils, pharynx, and base of the tongue), salivary glands, orbit, paranasal sinuses, and thyroid glands. There are several classification systems for categorizing NHL out of which WHO classification for lymphoid neoplasms is mostly followed. This review describes the pathogenesis of NHL and explains some of the important NHL (Marginal zone B-cell Lymphoma, follicular lymphoma, mantle cell lymphoma).
淋巴瘤是头颈部源自淋巴网状系统的第三大常见肿瘤。恶性淋巴瘤分为霍奇金病和非霍奇金淋巴瘤（NHL）。NHL约占头颈部恶性肿瘤的5%，其表现范围广泛，与霍奇金病相似。霍奇金淋巴瘤和非霍奇金淋巴瘤均可发生于头颈部，但在NHL患者中，结外病变（无论有无淋巴结受累）更为常见。结外受累部位包括瓦尔代尔环（即扁桃体、咽部和舌根）、唾液腺、眼眶、鼻窦和甲状腺等区域。有几种对NHL进行分类的系统，其中世界卫生组织的淋巴样肿瘤分类最为常用。本综述描述了NHL的发病机制，并解释了一些重要的NHL（边缘区B细胞淋巴瘤、滤泡性淋巴瘤、套细胞淋巴瘤）。
