Lu Ping
Department of Nuclear Medicine, Montefiore Medical Center, Bronx, NY.
Semin Nucl Med. 2005 Jul;35(3):160-4. doi: 10.1053/j.semnuclmed.2005.02.002.
In 2004, new cases of non-Hodgkin's lymphoma in the United States were estimated at 54,370, representing 4% of all cancers and resulting 4% of all cancer deaths, and new cases of Hodgkin's lymphoma were estimated at 7,880. The appropriate staging and management of lymphomas greatly depend on an accurate pathological diagnosis and classification. The recently established Revised European-American Classification of Lymphoid Neoplasms (REAL) and the subsequently adopted and updated World Health Organization (WHO) classification include modern cytogenetic, molecular, and immunologic techniques and knowledge and reach an international consensus on the classification of lymphomas. This classification scheme represents an advance in our understanding of lymphomas and serves as an operative guideline for studying and diagnosing lymphomas. Imaging techniques always have served as staging and monitoring tools for the clinical management of lymphomas. The understanding and adoption of the current classification system is important in refining the role of imaging modalities in the management of specific lymphoma. To help one understand the current classification, this current review gives a brief history of lymphoma classifications and summaries the recent classification schemes, including new entities, clinical staging methods, and clinical prognostic criteria.
2004年，美国非霍奇金淋巴瘤新发病例估计为54,370例，占所有癌症的4%，导致的癌症死亡占所有癌症死亡的4%，霍奇金淋巴瘤新发病例估计为7,880例。淋巴瘤的恰当分期和管理很大程度上取决于准确的病理诊断和分类。最近制定的《欧美淋巴瘤修订分类》（REAL）以及随后采用并更新的世界卫生组织（WHO）分类纳入了现代细胞遗传学、分子学和免疫学技术及知识，并在淋巴瘤分类方面达成了国际共识。这种分类方案代表了我们对淋巴瘤认识的进步，并作为研究和诊断淋巴瘤的操作指南。成像技术一直是淋巴瘤临床管理中的分期和监测工具。理解和采用当前分类系统对于完善成像模态在特定淋巴瘤管理中的作用很重要。为帮助人们理解当前分类，本综述简要介绍了淋巴瘤分类的历史，并总结了最近的分类方案，包括新实体、临床分期方法和临床预后标准。
