玻璃体腔内注射贝伐单抗对糖尿病性视网膜病变和视网膜分支静脉阻塞患者眼血流的影响：激光散斑血流图测量结果

The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy.

作者信息

Nitta Fumihiko, Kunikata Hiroshi, Aizawa Naoko, Omodaka Kazuko, Shiga Yukihiro, Yasuda Masayuki, Nakazawa Toru

机构信息

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan ; Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Japan.

出版信息

Clin Ophthalmol. 2014 Jun 11;8:1119-27. doi: 10.2147/OPTH.S62022. eCollection 2014.

BACKGROUND

This study evaluated the effect of intravitreal injection of bevacizumab (IVB) on macular edema associated with diabetic retinopathy (DME) or branch retinal vein occlusion (BRVOME) using laser speckle flowgraphy.

METHODS

A comparative interventional study of 25 eyes from 22 patients with macular edema (DME group: 12 eyes; BRVOME group: 13 eyes) who underwent IVB. Mean blur rate (MBR) was measured in the retinal artery, retinal vein, optic nerve head (ONH), and choroid before and after IVB.

RESULTS

In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04). In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively). In the DME group, pre-IVB MBR in the ONH was significantly correlated with post-IVB foveal thickness (R= -0.71, P=0.002). There was no such correlation in the BRVOME group in the ONH.

CONCLUSION

IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME. This suggests that this noninvasive and objective biomarker may be a useful part of pre-IVB evaluations and decision-making in DME.

背景

本研究使用激光散斑血流图评估玻璃体内注射贝伐单抗（IVB）对糖尿病性视网膜病变（DME）或视网膜分支静脉阻塞（BRVOME）相关黄斑水肿的影响。

方法

对22例黄斑水肿患者（DME组：12只眼；BRVOME组：13只眼）的25只眼进行IVB的对比干预研究。在IVB前后测量视网膜动脉、视网膜静脉、视神经乳头（ONH）和脉络膜的平均模糊率（MBR）。

结果

在BRVOME组中，视网膜动脉、视网膜静脉或ONH的MBR无显著变化，但脉络膜MBR显著降低（P = 0.04）。在DME组中，视网膜动脉、视网膜静脉、ONH和脉络膜的MBR均显著降低（分别为P = 0.02、P = 0.04、P < 0.001和P = 0.04）。在DME组中，ONH的IVB前MBR与IVB后黄斑中心凹厚度显著相关（R = -0.71，P = 0.002）。在BRVOME组的ONH中没有这种相关性。