经内镜超声引导下细针穿刺细胞学诊断的壁内食管平滑肌瘤：2例的细胞学和免疫细胞化学特征
Intraparietal esophageal leiomyomas diagnosed by endoscopic ultrasound-guided fine-needle aspiration cytology: Cytological and immunocytochemical features in two cases.
作者信息
Todaro P, Crinò S F, Ieni A, Pallio S, Consolo P, Tuccari G
机构信息
Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, I-98125 Italy.
Digestive Endoscopy Unit, Hospital Health Network 'Polyclinic G. Martino', University of Messina, Messina, I-98125 Italy.
出版信息
Oncol Lett. 2014 Jul;8(1):123-126. doi: 10.3892/ol.2014.2077. Epub 2014 Apr 16.
Endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) has proven to be of significant value as a diagnostic method for the evaluation of esophageal mesenchymal tumors, such as true leiomyomas. Utilizing the cell block procedure, the present study reports the diagnostic approach of EUS-FNAC in two patients affected by this lesion, describing the cytological and immunocytochemical findings. Spindle-shaped elements with elongated nuclei were appreciable; moreover, the cytoplasmatic immunohistochemical positivity for smooth muscle actin and desmin strongly supported the diagnosis of leiomyoma when also taking into account the constant negativity for CD34, CD117 and S100. The differential diagnosis between spindle cell mesenchymal tumors and leiomyomas, and the clinico-therapeutic management of the latter are also discussed in the study.
内镜超声引导下细针穿刺细胞学检查（EUS-FNAC）已被证明作为一种诊断方法，对于评估食管间叶性肿瘤，如真性平滑肌瘤具有重要价值。本研究采用细胞块法，报告了EUS-FNAC对两名患有该病变患者的诊断方法，描述了细胞学和免疫细胞化学检查结果。可见具有细长核的梭形细胞成分；此外，平滑肌肌动蛋白和结蛋白的细胞质免疫组化阳性强烈支持平滑肌瘤的诊断，同时还要考虑到CD34、CD117和S100持续呈阴性。本研究还讨论了梭形细胞间叶性肿瘤与平滑肌瘤的鉴别诊断以及后者的临床治疗处理。
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