Todaro P, Crinò S F, Pallio S, Fazzari C, Consolo P, Tuccari G
Department of Human Pathology, University of Messina, University-Hospital Health Network 'Polyclinic G. Martino', Messina I-98125, Italy.
Oncol Lett. 2013 Jun;5(6):1862-1866. doi: 10.3892/ol.2013.1296. Epub 2013 Apr 10.
The present study reports the diagnostic utility of endoscopic ultrasound-guided fine needle aspiration (EUS-FNAC) in two patients affected by gastrointestinal stromal tumours (GISTs) of the stomach. Clinically, the patients demonstrated skin pallor, melena, gastric discomfort and pain that had lasted three days or weeks. The cytological findings are discussed; these were strongly supported by immunocytochemical procedures that were performed on cell blocks and further confirmed following post-surgical histopathological examination. The crucial aim of GIST management is to determine a correct diagnosis in early-phase disease in order to realize an adequate curative surgical resection before the tumour becomes unresectable or metastatic. Moreover, a correct pre-surgical differential diagnosis of GISTs from other mesenchymal neoplasms may be easily made by EUS-FNAC, supported by cytological and immunocytochemical features.
本研究报告了内镜超声引导下细针穿刺抽吸术（EUS-FNAC）在两名患有胃胃肠道间质瘤（GIST）患者中的诊断效用。临床上，患者表现出皮肤苍白、黑便、胃部不适和疼痛，这些症状持续了三天或数周。对细胞学检查结果进行了讨论；细胞块上进行的免疫细胞化学程序有力地支持了这些结果，并在术后组织病理学检查后得到进一步证实。GIST管理的关键目标是在疾病早期确定正确诊断，以便在肿瘤变得无法切除或转移之前实现充分的根治性手术切除。此外，借助细胞学和免疫细胞化学特征，EUS-FNAC可轻松对GIST与其他间质性肿瘤进行正确的术前鉴别诊断。
