Kim Chang-Hee, Shin Jung Eun, Roh Hong Gee, Lee Jong Sik, Yoon So Young
Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 143-729, Republic of Korea.
Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 143-729, Republic of Korea.
Oncol Lett. 2014 Jul;8(1):394-396. doi: 10.3892/ol.2014.2058. Epub 2014 Apr 10.
Internal auditory canal (IAC) metastasis due to leptomeningeal carcinomatosis (LMC) from gastric cancer (GC) has rarely been reported. Early manifestation of symptoms, such as hearing loss, vertigo and facial paralysis, in cases of IAC metastasis due to LMC may facilitate the early detection of brain metastasis. To the best of our knowledge, the present study is the first to report IAC metastasis due to LMC in human epidermal growth factor receptor 2 (Her2)-positive GC. This study reports a case of an Her2-positive GC patient with LMC including IAC metastasis, who presented with acute sensorineural hearing loss, ipsilateral facial paralysis and vertigo during trastuzumab containing chemotherapy. The current study also discusses the early diagnosis and management of this complicated condition, demonstrating that clinical suspicion is key for a prompt diagnosis and proper management of LMC including IAC metastasis in Her2-positive GC.
胃癌（GC）导致的软脑膜癌病（LMC）引起的内耳道（IAC）转移鲜有报道。LMC导致的IAC转移病例中，听力丧失、眩晕和面瘫等症状的早期表现可能有助于脑转移的早期检测。据我们所知，本研究是首例报道人表皮生长因子受体2（Her2）阳性GC中LMC导致的IAC转移。本研究报告了1例Her2阳性GC患者发生LMC并伴有IAC转移，该患者在含曲妥珠单抗的化疗期间出现急性感音神经性听力丧失、同侧面瘫和眩晕。本研究还讨论了这种复杂疾病的早期诊断和管理，表明临床怀疑是快速诊断和妥善管理Her2阳性GC中包括IAC转移的LMC的关键。
