聚乙二醇-熊果酸共轭物：合成与体外释放研究

PEG-Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies.

作者信息

Zacchigna Marina, Cateni Francesca, Drioli Sara, Procida Giuseppe, Altieri Tiziano

机构信息

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.

School of Advanced Studies "G. D'Annunzio", University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo, Chieti, Italy.

出版信息

Sci Pharm. 2014 Apr 6;82(2):411-21. doi: 10.3797/scipharm.1309-17. Print 2014 Apr-Jun.

A highly water-soluble macromolecular compound of ursolic acid with monomethoxypoly(ethylene glycol) (mPEG) was prepared. The physicochemical properties and stabilities under different conditions were investigated. By PEG conjugation, greatly increased water solubility was obtained, and the results showed that this conjugate was a potential prodrug for the oral delivery of ursolic acid.