Liu Ruozhuo, Ma Minghui, Cui Mingyu, Dong Zhao, Wang Xiaolin, Zhang Wei, Yang Minghui, Yu Shengyuan
Department of Neurology, Chinese PLA General Hospital, Beijing, China.
Ministry of Resource Construction, Medical Library of the Chinese PLA, Academy of Military Medical Sciences, Beijing, China.
PLoS One. 2014 Jun 24;9(6):e100189. doi: 10.1371/journal.pone.0100189. eCollection 2014.
Genetic factors including TNF-β have been considered as important components in the aetiology of migraine. Many studies have investigated the association between TNF-β 252A>G polymorphism and migraine risk, with debatable results. This study was designed to examine whether the TNF-β 252A>G polymorphism confers genetic susceptibility to migraine in diverse populations.
Studies eligible for this meta-analysis were searched in the PubMed, Embase, and CNKI by using the keywords "tumor necrosis factor", "TNF", "252A>G", "rs909253", "polymorphism", "polymorphisms", "variant", "SNP", combined with "migraine" or "migraine with aura (MA)" or "migraine without aura (MO)". Pooled ORs and 95% CI were appropriately calculated using the fixed-effect model.
We finally included a total of seven studies, providing 5 557 migraineurs and 20 543 unrelated healthy controls. Meta-analysis results showed no statistical evidence of a significant association between TNF-β 252A>G polymorphism and overall migraine risk. Stratified analyses by type of migraine and gender revealed similar results. Interestingly, an OR with 95% CI representing an increased migraine risk was indicated in Asians under the recessive model (GG vs. AG + AA: OR, 1.38; 95%CI, 1.04-1.84; P for heterogeneity, 0.665).
Our findings appear to support the hypothesis that genetic variability of 252A>G polymorphism in TNF region may modulate risk of migraine in the population of Asian ancestry.
包括肿瘤坏死因子-β（TNF-β）在内的遗传因素被认为是偏头痛病因的重要组成部分。许多研究调查了TNF-β 252A>G多态性与偏头痛风险之间的关联，结果存在争议。本研究旨在探讨TNF-β 252A>G多态性是否赋予不同人群偏头痛的遗传易感性。
通过在PubMed、Embase和中国知网中使用关键词“肿瘤坏死因子”“TNF”“252A>G”“rs909253”“多态性”“多态性”“变体”“单核苷酸多态性”，并结合“偏头痛”或“有先兆偏头痛（MA）”或“无先兆偏头痛（MO）”来检索符合本荟萃分析的研究。使用固定效应模型适当计算合并比值比（OR）和95%可信区间（CI）。
我们最终纳入了总共7项研究，提供了5557例偏头痛患者和20543例无关健康对照。荟萃分析结果显示，没有统计学证据表明TNF-β 252A>G多态性与总体偏头痛风险之间存在显著关联。按偏头痛类型和性别进行的分层分析显示了类似结果。有趣的是，在隐性模型下，亚洲人显示出代表偏头痛风险增加的OR及95%CI（GG与AG + AA相比：OR，1.38；95%CI，1.04 - 1.84；异质性P值，0.665）。
我们的研究结果似乎支持这样一种假设，即TNF区域252A>G多态性的遗传变异可能调节亚洲血统人群患偏头痛的风险。
