Mandel L, Talafantová M, Trebichavský I, Trávnícek J
Department of Gnotobiology, Czechoslovak Academy of Sciences, Prague.
Folia Microbiol (Praha). 1989;34(1):68-76. doi: 10.1007/BF02821326.
The concentration of active phagocytes in peripheral blood remained in germfree pigs up to the age of one year approximately at the same level as found at the age of 7 d and did not exceed 0.3 X 10(9)/L of blood, whereas a steady increase was established in conventional pigs. Monoassociation of gnotobiotic piglets with Streptococcus faecalis increased during 24 h the concentration of circulating granulocytes and the concentration of active phagocytes. An even more pronounced effect was obtained when formolized S. faecalis cells were applied intraperitoneally to germfree piglets. This treatment elevated the phagocytosis index also in conventional piglets, as well as in germfree piglets previously given cyclophosphamide. Escherichia coli O 83 or a mixture of anaerobic bacteria did not cause any serious changes in the activity of phagocytosis in gnotobiotic piglets. S. faecalis seems to be a natural factor stimulating both the release of granulocytes from their depots as well as their phagocytic activity.
无菌猪外周血中活性吞噬细胞的浓度在一岁前一直保持在与7日龄时大致相同的水平，且不超过每升血液0.3×10⁹个，而普通猪的该浓度则稳步上升。无菌仔猪与粪链球菌单联后，循环粒细胞浓度和活性吞噬细胞浓度在24小时内增加。当将甲醛处理过的粪链球菌细胞腹腔注射给无菌仔猪时，效果更为显著。这种处理还提高了普通仔猪以及先前接受过环磷酰胺处理的无菌仔猪的吞噬指数。大肠杆菌O 83或厌氧菌混合物对无菌仔猪的吞噬活性未造成任何严重变化。粪链球菌似乎是刺激粒细胞从其储存库释放及其吞噬活性的天然因素。
