Zhang Tiejun, Liu Ying, Zhang Yuyan, Wang Jun, Minhas Veenu, Wood Charles, He Na
Department of Epidemiology, School of Public Health, Fudan University, and The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, China.
Putuo District Center for Disease Control and Prevention, Shanghai 200032, China.
Viruses. 2014 Jun 23;6(6):2519-30. doi: 10.3390/v6062519.
To elucidate and compare the seroprevalence of human herpesvirus 8 (HHV8) and hepatitis C virus (HCV) among Chinese drug users, a cross-sectional study of 441 participants, was conducted in Shanghai, China, from 2012 through 2013. Seventy-seven (17.5%) participants were found to be positive for HHV8 antibodies, while 271 (61.5%) participants were positive for HCV. No significant association between HHV8 seropositivity and drug use characteristics, sexual behaviors, HCV, or syphilis was observed. In contrast, a statistically significant association between HCV seropositivity and injected drug history (OR, 2.18, 95% CI 1.41-3.37) was detected, whereas no statistically significant association between HCV seropositivity and syphilis infection (OR, 7.56, 95% CI 0.94-60.57) were observed. Pairwise comparisons showed no significant differences between latent and lytic antibodies regarding HCV and HHV8 serostatus. The study demonstrated a moderate but elevated prevalence of HHV8 infection among drug users. The discordance between HHV8 and HCV infections suggests that blood borne transmission of HHV8 might not be the predominant mode of transmission in this population, which is in contrast to HCV.
为阐明并比较中国吸毒者中人类疱疹病毒8型（HHV8）和丙型肝炎病毒（HCV）的血清阳性率，于2012年至2013年在中国上海对441名参与者进行了一项横断面研究。发现77名（17.5%）参与者HHV8抗体呈阳性，而271名（61.5%）参与者HCV呈阳性。未观察到HHV8血清阳性与吸毒特征、性行为、HCV或梅毒之间存在显著关联。相比之下，检测到HCV血清阳性与注射吸毒史之间存在统计学显著关联（比值比，2.18，95%置信区间1.41 - 3.37），而未观察到HCV血清阳性与梅毒感染之间存在统计学显著关联（比值比，7.56，95%置信区间0.94 - 60.57）。成对比较显示，就HCV和HHV8血清状态而言，潜伏抗体和裂解抗体之间无显著差异。该研究表明吸毒者中HHV8感染率处于中等水平但有所升高。HHV8和HCV感染之间的不一致表明，HHV8的血源性传播可能不是该人群中的主要传播方式，这与HCV相反。
