AGR2 通过干扰素耦联细胞骨架抑制调控甾体代谢依赖体液免疫应答的肺腺癌转移新机制网络。

AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.

机构信息

Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

出版信息

Cell Immunol. 2014 Jul;290(1):102-6. doi: 10.1016/j.cellimm.2014.05.008. Epub 2014 Jun 11.

DOI:10.1016/j.cellimm.2014.05.008

PMID:24960290

Abstract

7 anterior gradient homolog 2 (AGR2)-inhibited different molecular mutual positive correlation network was constructed in lung adenocarcinoma compared with human normal adjacent tissues by 17 overlapping molecules of 358 GRNInfer and 19 Pearson (AGR2 CC⩽-0.25). Based on GO, KEGG, GenMAPP, BioCarta and disease databases, we determined AGR2-mediated lung adenocarcinoma metastasis through repression with cytoskeleton of MAST1; steroid metabolism of SOAT2; humoral immune response of POU2AF1; interferon alpha-inducible of IFI6; immunoglobulin of IGKC_3, CTA_246H3.1. Thus we proposed AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.

摘要

7 个 AGR2 抑制的分子互作网络在肺腺癌和正常相邻组织中存在差异，该差异通过 GRNInfer 的 358 个重叠分子和 19 个 Pearson 相关系数确定（AGR2 CC ⩽-0.25）。基于 GO、KEGG、GenMAPP、BioCarta 和疾病数据库，我们确定 AGR2 通过抑制 MAST1 的细胞骨架、SOAT2 的甾体代谢、POU2AF1 的体液免疫反应、IFI6 的干扰素α诱导、IGKC_3、CTA_246H3.1 的免疫球蛋白，来介导肺腺癌转移。因此，我们提出了 AGR2 介导的肺腺癌转移的新机制网络，该网络通过干扰素抑制细胞骨架与甾体代谢依赖的体液免疫反应相耦合。