重组人肿瘤坏死因子α对小鼠抗单核细胞增多性李斯特菌感染的保护作用。
Protection of mice against Listeria monocytogenes infection by recombinant human tumor necrosis factor alpha.
作者信息
Desiderio J V, Kiener P A, Lin P F, Warr G A
机构信息
Department of Microbiology, Bristol-Myers Co., Wallingford, Connecticut 06492.
出版信息
Infect Immun. 1989 May;57(5):1615-7. doi: 10.1128/iai.57.5.1615-1617.1989.
Abstract
Recombinant human tumor necrosis factor alpha (rHuTNF-alpha) administered intravenously to mice resulted in enhanced resistance to a lethal challenge infection of Listeria monocytogenes given 24 h later. The observed protection was lost following treatment of the rHuTNF-alpha preparations with rabbit polyclonal antibody rHuTNF-alpha but not with normal rabbit immunoglobulin G.
摘要
给小鼠静脉注射重组人肿瘤坏死因子α（rHuTNF-α）后，可增强其对24小时后给予的单核细胞增生李斯特菌致死性攻击感染的抵抗力。用兔多克隆抗体rHuTNF-α处理rHuTNF-α制剂后，观察到的保护作用消失，但用正常兔免疫球蛋白G处理则不会。
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本文引用的文献
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Infect Immun. 1980 Nov;30(2):523-30. doi: 10.1128/iai.30.2.523-530.1980.
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Pharmacokinetics of murine tumor necrosis factor.小鼠肿瘤坏死因子的药代动力学
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Production of tumor necrosis factor during murine listeriosis.小鼠李斯特菌病期间肿瘤坏死因子的产生
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Cachectin: more than a tumor necrosis factor.恶病质素：不仅仅是一种肿瘤坏死因子。
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Tumor necrosis factor and interleukin 1 as mediators of endotoxin-induced beneficial effects.肿瘤坏死因子和白细胞介素1作为内毒素诱导的有益作用的介质。
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