Occupational Respiratory Epidemiology, School of Population Health, University of Western Australia, Perth, Western Australia 6009, Australia.
Monash Centre for Occupational and Environmental Health, Monash University, Melbourne, Victoria 3004, Australia.
Br J Cancer. 2014 Aug 26;111(5):998-1003. doi: 10.1038/bjc.2014.358. Epub 2014 Jun 24.
Parental occupational exposures have been associated with childhood brain tumours (CBT), but results are inconsistent. Few studies have studied CBT risk and parental solvent exposure, suggesting a possible association. We examined the association between CBT and parental occupational exposure to solvents in a case-control study.
Parents of 306 cases and 950 controls completed detailed occupational histories. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for both maternal and paternal exposure to benzene, other aromatics, aliphatics and chlorinated solvents in key time periods relative to the birth of their child. Adjustments were made for matching variables (child's age, sex and state of residence), best parental education and occupational exposure to diesel exhaust.
An increased risk of CBT was observed with maternal occupational exposures to chlorinated solvents (OR=8.59, 95% CI 0.94-78.9) any time before birth. Paternal exposure to solvents in the year before conception was associated with an increased CBT risk: OR=1.55 (95% CI 0.99-2.43). This increased risk appeared to be mainly attributable to exposure to aromatic solvents: OR=2.72 (95% CI 0.94-7.86) for benzene and OR=1.76 (95% CI 1.10-2.82) for other aromatics.
Our results indicate that parental occupational exposures to solvents may be related to an increased risk of CBT.
父母的职业暴露与儿童脑肿瘤（CBT）有关，但结果不一致。很少有研究探讨过 CBT 风险与父母接触溶剂之间的关系，表明两者之间可能存在关联。我们在一项病例对照研究中，研究了 CBT 与父母职业暴露于溶剂之间的关系。
306 名病例儿童的父母和 950 名对照儿童的父母完成了详细的职业史。针对儿童出生前后的关键时期，分别估计了母亲和父亲接触苯、其他芳香族化合物、脂肪族化合物和氯化溶剂的比值比（OR）及其 95%置信区间（CI）。调整了匹配变量（儿童的年龄、性别和居住州）、父母最高教育程度和接触柴油废气的情况。
在整个怀孕期间，母亲职业性接触氯化溶剂与 CBT 风险增加相关（OR=8.59，95%CI 0.94-78.9）。父亲在受孕前一年接触溶剂与 CBT 风险增加相关：OR=1.55（95%CI 0.99-2.43）。这种风险增加似乎主要归因于接触芳香族溶剂：接触苯的 OR=2.72（95%CI 0.94-7.86），接触其他芳香族化合物的 OR=1.76（95%CI 1.10-2.82）。
我们的研究结果表明，父母职业暴露于溶剂可能与 CBT 风险增加有关。
