Le Cornet Charlotte, Fervers Béatrice, Pukkala Eero, Tynes Tore, Feychting Maria, Hansen Johnni, Togawa Kayo, Nordby Karl-Christian, Oksbjerg Dalton Susanne, Uuksulainen Sanni, Wiebert Pernilla, Woldbæk Torill, Skakkebæk Niels E, Olsson Ann, Schüz Joachim
Section of Environment and Radiation, International Agency for Research on Cancer (IARC) , Lyon, France.
Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum (DKFZ) , Heidelberg, Germany.
Environ Health Perspect. 2017 Jun 30;125(6):067023. doi: 10.1289/EHP864.
Testicular germ cell tumors (TGCT) were suggested to have a prenatal environmentally related origin. The potential endocrine disrupting properties of certain solvents may interfere with the male genital development .
We aimed to assess the association between maternal and paternal occupational exposures to organic solvents during the prenatal period and TGCT risk in their offspring.
This registry-based case control study included TGCT cases aged 14–49 y (=8,112) diagnosed from 1978 to 2012 in Finland, Norway, and Sweden. Controls (=26,264) were randomly selected from the central population registries and were individually matched to cases on year and country of birth. Occupational histories of parents prior to the child’s birth were extracted from the national censuses. Job codes were converted into solvent exposure using the Nordic job-Nordic Occupational Cancer Study Job-Exposure Matrix. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI).
Overall, no association was found between prenatal maternal exposure to solvents and TGCT risk. In subset analyses using only mothers for whom occupational information was available in the year of or in the year prior to the child’s birth, there was an association with maternal exposure to aromatic hydrocarbon solvents (ARHC) (OR=1.53; CI: 1.08, 2.17), driven by exposure to toluene (OR=1.67; CI: 1.02, 2.73). No association was seen for any paternal occupational exposure to solvents with the exception of exposure to perchloroethylene in Finland (OR=2.42; CI: 1.32, 4.41).
This study suggests a modest increase in TGCT risk associated with maternal prenatal exposure to ARHC. https://doi.org/10.1289/EHP864.
睾丸生殖细胞肿瘤（TGCT）被认为起源于产前与环境相关的因素。某些溶剂潜在的内分泌干扰特性可能会干扰男性生殖器发育。
我们旨在评估产前母亲和父亲职业性接触有机溶剂与后代患TGCT风险之间的关联。
这项基于登记处的病例对照研究纳入了1978年至2012年在芬兰、挪威和瑞典诊断出的14至49岁的TGCT病例（n = 8112）。对照（n = 26264）从中央人口登记处随机选取，并根据出生年份和国家与病例进行个体匹配。孩子出生前父母的职业史从全国人口普查中提取。使用北欧职业-北欧职业癌症研究工作-暴露矩阵将工作代码转换为溶剂暴露情况。采用条件逻辑回归来估计比值比（OR）和95%置信区间（CI）。
总体而言，未发现产前母亲接触溶剂与TGCT风险之间存在关联。在仅对孩子出生当年或前一年有职业信息的母亲进行的亚组分析中，发现母亲接触芳烃溶剂（ARHC）与TGCT风险存在关联（OR = 1.53；CI：1.08，2.17），主要由接触甲苯所致（OR = 1.67；CI：1.02，2.73）。除芬兰父亲接触全氯乙烯外（OR = 2.42；CI：1.32，4.41），未发现父亲任何职业性接触溶剂与TGCT风险存在关联。
本研究表明，产前母亲接触ARHC会使TGCT风险适度增加。https://doi.org/10.1289/EHP864
