Wadelius M, Marshall S E, Islander G, Nordang L, Karawajczyk M, Yue Q-Y, Terreehorst I, Baranova E V, Hugosson S, Sköldefors K, Pirmohamed M, Maitland-van der Zee A-H, Alfirevic A, Hallberg P, Palmer C N A
Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Medical Research Institute, College of Medicine, Dentistry and Nursing, University of Dundee, Ninewells Hospital, Dundee, UK.
Clin Pharmacol Ther. 2014 Oct;96(4):477-81. doi: 10.1038/clpt.2014.138. Epub 2014 Jun 24.
Angioedema is a potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicenter recruitment of patients are needed. To reduce patient heterogeneity, we have standardized the phenotype. In brief, it comprises swelling in the head and neck region that first occurs during treatment. It should not coincide with urticaria or have another likely cause such as hereditary angioedema.
血管性水肿是对血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂的一种潜在危及生命的不良反应。为研究这种罕见不良事件的遗传病因，需要国际联盟以及多中心招募患者。为减少患者异质性，我们对表型进行了标准化。简而言之，它包括在治疗期间首次出现的头颈部肿胀。它不应与荨麻疹同时出现，也不应有其他可能的原因，如遗传性血管性水肿。
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