初级纤毛和鞭毛内运输蛋白在骨骼中的功能及调控
Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton.
作者信息
Yuan Xue, Serra Rosa A, Yang Shuying
机构信息
Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, New York.
出版信息
Ann N Y Acad Sci. 2015 Jan;1335(1):78-99. doi: 10.1111/nyas.12463. Epub 2014 Jun 24.
Primary cilia are microtubule-based organelles that project from the cell surface to enable transduction of various developmental signaling pathways. The process of intraflagellar transport (IFT) is crucial for the building and maintenance of primary cilia. Ciliary dysfunction has been found in a range of disorders called ciliopathies, some of which display severe skeletal dysplasias. In recent years, interest has grown in uncovering the function of primary cilia/IFT proteins in bone development, mechanotransduction, and cellular regulation. We summarize recent advances in understanding the function of cilia and IFT proteins in the regulation of cell differentiation in osteoblasts, osteocytes, chondrocytes, and mesenchymal stem cells (MSCs). We also discuss the mechanosensory function of cilia and IFT proteins in bone cells, cilia orientation, and other functions of cilia in chondrocytes.
原发性纤毛是基于微管的细胞器，从细胞表面伸出以实现各种发育信号通路的转导。鞭毛内运输（IFT）过程对于原发性纤毛的构建和维持至关重要。在一系列称为纤毛病的疾病中发现了纤毛功能障碍，其中一些表现出严重的骨骼发育不良。近年来，人们对揭示原发性纤毛/IFT蛋白在骨骼发育、机械转导和细胞调节中的功能越来越感兴趣。我们总结了在理解纤毛和IFT蛋白在成骨细胞、骨细胞、软骨细胞和间充质干细胞（MSC）细胞分化调节中的功能方面的最新进展。我们还讨论了纤毛和IFT蛋白在骨细胞中的机械感觉功能、纤毛方向以及纤毛在软骨细胞中的其他功能。
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