Lechtreck Karl F, Van De Weghe Julie C, Harris James Aaron, Liu Peiwei
Department of Cellular Biology, University of Georgia, Athens, Georgia.
Traffic. 2017 May;18(5):277-286. doi: 10.1111/tra.12474. Epub 2017 Mar 29.
Cilia and eukaryotic flagella are threadlike cell extensions with motile and sensory functions. Their assembly requires intraflagellar transport (IFT), a bidirectional motor-driven transport of protein carriers along the axonemal microtubules. IFT moves ample amounts of structural proteins including tubulin into growing cilia likely explaining its critical role for assembly. IFT continues in non-growing cilia contributing to a variety of processes ranging from axonemal maintenance and the export of non-ciliary proteins to cell locomotion and ciliary signaling. Here, we discuss recent data on cues regulating the type, amount and timing of cargo transported by IFT. A regulation of IFT-cargo interactions is critical to establish, maintain and adjust ciliary length, protein composition and function.
纤毛和真核生物鞭毛是具有运动和感觉功能的丝状细胞延伸物。它们的组装需要鞭毛内运输（IFT），这是一种沿着轴丝微管的双向马达驱动的蛋白质载体运输。IFT将包括微管蛋白在内的大量结构蛋白运入生长中的纤毛，这可能解释了它在组装中的关键作用。IFT在不生长的纤毛中持续存在，有助于从轴丝维持、非纤毛蛋白输出到细胞运动和纤毛信号传导等各种过程。在这里，我们讨论了关于调节IFT运输的货物类型、数量和时间的线索的最新数据。IFT-货物相互作用的调节对于建立、维持和调整纤毛长度、蛋白质组成和功能至关重要。
