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肾移植患者播散性拜氏 Cunninghamella 菌感染合并脊髓硬膜外脓肿:病例报告及文献综述

Disseminated Cunninghamella bertholletiae infection with spinal epidural abscess in a kidney transplant patient: case report and literature review.

作者信息

Navanukroh O, Jitmuang A, Chayakulkeeree M, Ngamskulrungroj P

机构信息

Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Transpl Infect Dis. 2014 Aug;16(4):658-65. doi: 10.1111/tid.12251. Epub 2014 Jun 24.

Abstract

Cunninghamella bertholletiae is a rare cause of invasive mucormycosis. We report the case of a 42-year-old Thai woman who suffered from disseminated C. bertholletiae infection. The patient developed dry cough, sharp shooting pain in the left buttock referred to the left leg, and fever 1 month after undergoing deceased-donor kidney transplantation. Radiographic studies exhibited multiple pulmonary cavities, osteomyelitis of the sacral spine, epidural abscess along the lumbrosacral spine, and paravertebral soft tissue involvement. Surgical debridement of the epidural abscess concurrent with prolonged intravenous administration of amphotericin B resulted in a good outcome.

摘要

伯氏小克银汉霉是侵袭性毛霉病的罕见病因。我们报告了一例42岁泰国女性发生播散性伯氏小克银汉霉感染的病例。该患者在接受已故供体肾移植1个月后出现干咳、左臀部牵涉至左腿的剧烈刺痛和发热。影像学检查显示多个肺空洞、骶椎骨髓炎、腰骶部硬膜外脓肿以及椎旁软组织受累。硬膜外脓肿的手术清创术联合长时间静脉注射两性霉素B取得了良好疗效。

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