“高住低练”对超重中国青少年体重减轻的影响：一项随机对照试验的研究方案

The effect of 'sleep high and train low' on weight loss in overweight Chinese adolescents: study protocol for a randomized controlled trial.

作者信息

Wang Ru, Liu Dongmei, Wang Xueqiang, Xiao Weihua, Wu Nana, Gao Binghong, Chen Peijie

机构信息

Key Laboratory of Exercise and Health Sciences of Ministry of Education at the Shanghai University of Sport, #650 Qingyuanhuan Road, Shanghai 200438, China.

出版信息

Trials. 2014 Jun 25;15:250. doi: 10.1186/1745-6215-15-250.

DOI:10.1186/1745-6215-15-250

PMID:24962246

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4082418/

Abstract

BACKGROUND

Exercise and diet are the cornerstones for the treatment of obesity in obese children and adolescents. However, compensatory changes in appetite and energy expenditure elicited by exercise and dieting make it hard to maintain a reduced weight over the longterm. The anorexic effect of hypoxia can be potentially utilized to counteract this compensatory increase, thereby enhancing the success of weight loss. The purpose of the study is to assess the effectiveness of four week intermittent hypoxia exposure added to a traditional exercise and diet intervention on inducing short- and longterm weight loss in obese adolescents.

METHODS/DESIGN: In this randomized parallel group controlled clinical trial, 40 obese adolescents (20 boys and 20 girls, 11 to 15-years-old), will be recruited from a summer weight loss camp at the Shanghai University of Sport, China. Participants will be stratified by gender and randomly assigned to either the control group or the hypoxia group. During the four-week intervention period, both groups will exercise and eat a balanced diet. Additionally, the control group will sleep in normal conditions, while the hypoxia group will sleep in a normobaric hypoxia chamber (sleep high and train low). The primary outcome will be body composition and the main secondary outcomes will be the circulating levels of appetite regulatory gastrointestinal hormones. All the outcome measures will be assessed at baseline, after the four-week intervention, and at two months follow-up.

DISCUSSION

Our study will be the first to evaluate the effectiveness of 'sleep high and train low' on short- and longterm weight loss among obese adolescents. A potential mechanism for the appetite regulatory effect of hypoxia will also be explored. The results of the study will provide an evidence-based recommendation for the use of hypoxia in a weight loss intervention among obese children and adolescents. Furthermore, the clarification of mechanisms leading to weight loss in 'sleep high and train low' might provide information for the development of new strategies in combating obesity.

TRIAL REGISTRATION

This trial was registered on 10 January 2014 at the Chinese Clinical Trial Registry with the registration number: ChiCTR-TRC-14004106.

摘要

背景

运动和饮食是肥胖儿童及青少年肥胖治疗的基石。然而，运动和节食引发的食欲及能量消耗的代偿性变化使得长期维持减重效果变得困难。缺氧的厌食效应有可能被用来抵消这种代偿性增加，从而提高减肥的成功率。本研究的目的是评估在传统运动和饮食干预基础上增加为期四周的间歇性缺氧暴露对肥胖青少年短期和长期减重的有效性。

方法/设计：在这项随机平行组对照临床试验中，将从中国上海体育学院的一个夏季减肥营招募40名肥胖青少年（20名男孩和20名女孩，11至15岁）。参与者将按性别分层，并随机分配到对照组或缺氧组。在为期四周的干预期内，两组都将进行运动并食用均衡饮食。此外，对照组将在正常条件下睡眠，而缺氧组将在常压低氧舱中睡眠（高住低练）。主要结局将是身体成分，主要次要结局将是食欲调节性胃肠激素的循环水平。所有结局指标将在基线、四周干预后以及两个月随访时进行评估。