Yang Qin, Huang Guoyuan, Tian Qianqian, Liu Wei, Sun Xiangdong, Li Na, Sun Shunli, Zhou Tang, Wu Nana, Wei Yuqin, Chen Peijie, Wang Ru
Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, China Pott College of Science, Engineering and Education, University of Southern Indiana, Evansville, IN.
Medicine (Baltimore). 2018 Feb;97(8):e9943. doi: 10.1097/MD.0000000000009943.
"Living High-Training Low" (LHTL) is effective for the improvement of athletic ability; however, little is known about the effect of LHTL on obese individuals. The present study determined whether LHTL would have favorable influence on body composition, rebalance the appetite hormones, and explore the underlying mechanism.
Adolescents with obesity [body mass index (BMI) >30 kg/m] were randomly assigned to "Living Low-Training Low" (LLTL, n = 19) group that slept in a normobaric normoxia condition and the LHTL (n = 16) group slept in a normobaric hypoxia room (14.7% PO2 ∼2700 m). Both groups underwent the same aerobic exercise training program. Morphological, blood lipids, and appetite hormones were measured and assessed.
After the intervention, the body composition improved in both groups, whereas reductions in body weight (BW), BMI, and lean body mass increased significantly in the LHTL group (all, P < .05). In the LLTL group, cholecystokinin (CCK) decreased remarkably (P < .05) and CCK changes were positively associated with changes in BW (r = 0.585, P = .011) and BMI (r = 0.587, P = .010). However, in the LHTL group, changes in plasma glucagon-like peptide-1 (GLP-1) and interleukin-6 (IL-6) levels, positively correlated with each other (r = 0.708, P = .015) but negatively with BW changes (r = -0.608, P = .027 and r = -0.518, P = .048, respectively).
The results indicated that LHTL could induce more weight loss safely and efficiently as compared to LLTL and increase the plasma GLP-1 levels that may be mediated by IL-6 to rebalance the appetite. Thus, an efficient method to treat obesity and prevent weight regain by appetite rebalance in hypoxia condition was established.
“高住低训”（LHTL）对提高运动能力有效；然而，关于LHTL对肥胖个体的影响知之甚少。本研究确定LHTL是否会对身体成分产生有利影响，重新平衡食欲激素，并探究其潜在机制。
将肥胖青少年[体重指数（BMI）>30 kg/m²]随机分为“低住低训”（LLTL，n = 19）组，该组在常压常氧条件下睡眠，以及LHTL（n = 16）组，该组在常压缺氧室（氧分压14.7% ∼海拔2700米）睡眠。两组均进行相同的有氧运动训练计划。测量并评估形态学、血脂和食欲激素。
干预后，两组的身体成分均有所改善，而LHTL组的体重（BW）、BMI和去脂体重下降显著增加（均P < 0.05）。在LLTL组中，胆囊收缩素（CCK）显著降低（P < 0.05），且CCK变化与BW变化（r = 0.585，P = 0.011）和BMI变化（r = 0.587，P = 0.010）呈正相关。然而，在LHTL组中，血浆胰高血糖素样肽-1（GLP-1）和白细胞介素-6（IL-6）水平变化彼此呈正相关（r = 0.708，P = 0.015），但与BW变化呈负相关（分别为r = -0.608，P = 0.027和r = -0.518，P = 0.048）。
结果表明，与LLTL相比，LHTL能更安全有效地诱导更多体重减轻，并增加血浆GLP-1水平，这可能由IL-6介导以重新平衡食欲。因此，建立了一种在缺氧条件下通过食欲重新平衡来治疗肥胖和预防体重反弹的有效方法。
